[Role of genetic differences between mother and fetuses in the development of the graft vs host reaction induced in the mother]

Abstract

The development of the graft-versus-host reaction (GVHR) was studied in female (CBAxC57BL)F1 mice during pregnancy, after delivery or before mating with syngeneic, semisyngeneic and allogeneic males. It was found that the results in females depend on genetic differences between the donors of injected lymphoid cells and fetuses, as well as on the time of inducing GVHR. If lymphoid cells from C57BL/L mice were injected to (CBA X C57BL) females after delivery or before mating with CBA males of the parental strain, the gravidity promoted the enhancement of GVHR. Infection of lymphoid cells during pregnancy produced marked increases resistance ot GVHR. In case of mating with males of the contralateral paternal strain C57BL/6, gravidity did not influence GVHR irrespective the injection time.