Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jun 15;45(12):2929-33.
doi: 10.1002/1097-0142(19800615)45:12<2929::aid-cncr2820451205>3.0.co;2-9.

Specific and non-specific immunologic mechanisms of tumor growth facilitation

H Yamagishi, N R Pellis, M B Mokyr, B D Kahan

Specific and non-specific immunologic mechanisms of tumor growth facilitation

H Yamagishi et al. Cancer. .

Abstract

Specific and non-specific mechanisms of tumor growth facilitation were studied using methylcholanthrene (MCA)-induced fibrosarcomas in C3H/HeJ mice. In early and late stages of tumor growth, mice possessed non-specific, tumor-facilitating cells detected by local adoptive transfer assay (LATA). These cells appeared to be macrophages; they were radioresistant (700 rads), phagocytic, and adherent to plastic. Specific tumor facilitation was induced by treatment either with crude 3M KCl extracts, or with an acidic pIEF fraction (pI 3.5). After treatment with this material, animals displayed facilitated outgrowth of only MCA-F, but not the antigenically distinct MCA-D or MCA-C tumors. Thus in addition to non-specific stimuli, which accelerate neoplastic growth, tumors bear tumor-specific transplantation antigens (TSTA), which induce specific facilitation.

PubMed Disclaimer

LinkOut - more resources