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Clinical Trial
. 1980;4(2):129-32.
doi: 10.1007/BF00254034.

Low-dose cyclophosphamide versus adriamycin plus cyclophosphamide in advanced ovarian cancer. A randomized clinical study

G Bolis, G Bortolozzi, G Carinelli, M D'Incalci, F Gramellini, L Morasca, C Mangioni
Clinical Trial

Low-dose cyclophosphamide versus adriamycin plus cyclophosphamide in advanced ovarian cancer. A randomized clinical study

G Bolis et al. Cancer Chemother Pharmacol. 1980.

Abstract

After intensive staging 74 ovarian cancer patients were randomized to two arms balanced for stage and post-surgery residual tumor. The two regimens were CTX 100 mg/day continuously and ADM 50 mg/m2 IV every 4 weeks plus CTX 100 mg/day. The response rates were respectively 42% and 52%. Median survival times were 13 and 14 months. The incidence of side effects was significantly higher in the combination-treatment arm. No other statistical differences were found.

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