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. 1980 Jul;28(1):99-105.
doi: 10.1038/clpt.1980.137.

Kinetics of R andS warfarin enantiomers

C Hignite, J Uetrecht, C Tschanz, D Azarnoff

Kinetics of R andS warfarin enantiomers

C Hignite et al. Clin Pharmacol Ther. 1980 Jul.

Abstract

A method is reported for simultaneous measurement of the kinetics of R and S warfarin enantiomers. Pure pentadeuterated R and S enantiomers were each combined with unlabeled enatiomers to form "pseudo"-racemic mixtures which were given (0.75 mg/kg) to 5 healthy subjects. Plasma R and S enantiomer levels were measured by gas chromatography--mass spectrometry. Elimination half-lifes (t1/2S) and volumes of distribution (VdS) of the enantiomers were not altered by the presence of the other.

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