doi: 10.1016/s0140-6736(77)90441-x.
Immunological mechanism for spontaneous abortion in systemic lupus erythematosus
- PMID: 73904
- DOI: 10.1016/s0140-6736(77)90441-x
Item in Clipboard
Immunological mechanism for spontaneous abortion in systemic lupus erythematosus
Lancet.
.
Abstract
The incidence of lymphocytotoxic antibodies in patients with systemic lupus erythematosus (S.L.E.) was significantly lower during pregnancies ending in normal live births than in pregnancies ending in spontaneous abortions (P less than 0.005). It was possible to absorb the lymphocytotoxic antibodies from S.L.E. sera with purified trophoblast antigens. The presence of a trophoblast-reactive lymphocytotoxic antibody which fails to disappear during pregnancies which end in abortion suggests an immunological mechanism for spontaneous abortion in S.L.E.
Similar articles
-
Lymphocytotoxic antibodies during pregnancy in systemic lupus erythematosus.Lancet. 1979 May 12;1(8124):1034. doi: 10.1016/s0140-6736(79)92789-2. Lancet. 1979. PMID: 86753 No abstract available.
-
Systemic lupus erythematosus and pregnancy: clinical, immunological, and theoretical aspects.Prog Clin Biol Res. 1981;70:283-302. Prog Clin Biol Res. 1981. PMID: 6458823 Review. No abstract available.
-
Changes in anti-lymphocyte and anti-Ia antibodies during pregnancy in systemic lupus erythematosus.Clin Immunol Immunopathol. 1986 Aug;40(2):259-64. doi: 10.1016/0090-1229(86)90029-2. Clin Immunol Immunopathol. 1986. PMID: 2941195
-
Lupus erythematosus, the placenta, and pregnancy: a natural experiment in immunologically mediated reproductive failure.Prog Clin Biol Res. 1981;70:309-20. Prog Clin Biol Res. 1981. PMID: 7031694 Review. No abstract available.
-
[A longitudinal clinical study and laboratory survey of systemic lupus erythematosus].Harefuah. 1980 Mar 16;98(6):241-4. Harefuah. 1980. PMID: 7409641 Hebrew. No abstract available.
Cited by
-
Congenital heart block and maternal systemic lupus erythematosus.Br Med J. 1979 May 12;1(6173):1235-8. doi: 10.1136/bmj.1.6173.1235. Br Med J. 1979. PMID: 455010 Free PMC article.
-
Multiple autoantibodies associated with autoimmune reproductive failure.J Assist Reprod Genet. 2003 Feb;20(2):53-7. doi: 10.1023/a:1021716623305. J Assist Reprod Genet. 2003. PMID: 12688588 Free PMC article. Review.
-
Prevalence of antinuclear antibodies in patients with habitual abortion and in normal and toxemic pregnancies.Rheumatol Int. 1984;4(2):87-9. doi: 10.1007/BF00541202. Rheumatol Int. 1984. PMID: 6377452
-
Obstetric and gynaecological profile in patients with primary Sjögren's syndrome.Ann Rheum Dis. 1994 Sep;53(9):569-73. doi: 10.1136/ard.53.9.569. Ann Rheum Dis. 1994. PMID: 7979594 Free PMC article.
-
Lymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance.J Clin Pathol Suppl (R Coll Pathol). 1979;13:112-5. doi: 10.1136/jcp.s3-13.1.112. J Clin Pathol Suppl (R Coll Pathol). 1979. PMID: 293333 Free PMC article. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
