Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980;54(1):79-82.
doi: 10.1007/BF00279052.

Is there a relationship between sex of cystic fibrosis carriers and sex ratio of their offspring?

F Gloria-Bottini, M Antonelli, S Quattrucci, E Cardi, E Bottini

Is there a relationship between sex of cystic fibrosis carriers and sex ratio of their offspring?

F Gloria-Bottini et al. Hum Genet. 1980.

Abstract

Data on the offspring of 198 aunts and 179 uncles of 100 cystic fibrosis index cases were analyzed. Aunts showed higher average number of liveborn sons than uncles. No significant difference was observed in the number of liveborn female offspring. When the sample was subdivided with respect to family size, the proportion of liveborn sons of aunts appeared higher than that of uncles in all classes. The present observations suggest that a female carrier may have a higher probability of male offspring than a male carrier and that she may be mainly responsible for the sex ratio deviations previously reported in sibships of cystic fibrosis patients.

PubMed Disclaimer

References

    1. J Genet Hum. 1971 Dec;19(4):275-98 - PubMed
    1. Am J Hum Genet. 1967 May;19(3 Pt 2):388-92 - PubMed
    1. Bibl Paediatr. 1967;86:381-7 - PubMed
    1. Maandschr Kindergeneeskd. 1969 Nov;37(5):134-49 - PubMed
    1. N Engl J Med. 1976 Aug 26;295(9):481-5 - PubMed