Lymphocyte capping in hereditary muscular dystrophic chickens and mice: no evidence for a systemic membrane defect

Abstract

Splenic lymphocytes from both the Storrs and Davis strains of muscular dystrophic chickens and the C57BL/6J-2J strain of muscular dystrophic mice cap FITC-Con A and FITC-Ig in a manner similar to normal controls. In analyses of testcross progeny of Storrs muscular dystrophic chickens, no difference in the ability of lymphocytes to cap were observed among the segregating progeny. Neither were any significant differences observed in lymphocyte capping among F2 segregating progeny of C57BL/6J-2J mice. These studies do not support the systemic membrane defect hypothesis for muscular dystrophy.