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. 1980 Jun;23(6):682-4.
doi: 10.1021/jm00180a022.

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

V A Levin

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

V A Levin. J Med Chem. 1980 Jun.

Abstract

The rat brain capillary permeability coefficient was determined for 27 compounds. The relationship of permeability to octanol/water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400.

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