[Pharmacological correction of myocardial ischemia and arrhythmias in reversible coronary blood flow disorders and experimental myocardial infarct in dogs]

Abstract

The efficacy of the sum of alkaloids of the common fumitory in temporary disorders of the coronary blood flow in the circumflex artery was studied in chronic experiments on 8 dogs. Occlusion of the vessel was caused by means of a remote-controlled loop implanted into the thoracic wall. The arrest of circulation in the artery was attended by the appearance of pathological signs on the ECG in the form of tachycardia, growth of the T wave amplitude, and displacement of the RS-T interval. Preliminary injection of the drug in a dose of 1--2 mg/kg prevented completely or reduced to a great measure the ischemic shifts. In experiments on 6 dogs, 5.2 mg/kg dose of the drug relieved for 20 to 87 min the disorders of rhythm induced by ligation of the interventricular branch of the left coronary artery.