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. 1980 Apr;17(4):544-8.
doi: 10.1128/AAC.17.4.544.

Preparation and properties of liposome-associated gentamicin

J R Morgan, K E Williams

Preparation and properties of liposome-associated gentamicin

J R Morgan et al. Antimicrob Agents Chemother. 1980 Apr.

Abstract

Gentamicin was successfully incorporated into neutral, anionic, and cationic liposomes, and the percentage of gentamicin incorporated was found to be a function of lipid concentration. Gentamicin did not leak out of the liposomes over a 3-week period at 4 degrees C. When liposome-associated gentamicin was administered intravenously to rabbits, its serum half-life was greatly prolonged. Intragastric administration of dipalmitoylphosphatidylcholine liposomes containing gentamicin resulted in the appearance of gentamicin in serum. Liposome-associated gentamicin, when administered intravenously, led to the appearance of gentamicin in the liver and spleen, which was not observed when rabbits were injected with free gentamicin.

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