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. 1980 Jul;69(3):379-82.
doi: 10.1111/j.1476-5381.1980.tb07025.x.

Effects of oxytocin on the isolated vas deferens of the rat

J V Beneit, A Hidalgo, J L Tamargo

Effects of oxytocin on the isolated vas deferens of the rat

J V Beneit et al. Br J Pharmacol. 1980 Jul.

Abstract

1 The effect of oxytocin was studied on the isolated vas deferens of the rat. 2 Oxytocin (25 to 200 mu/ml) reversibly reduced the contractile response induced by noradrenaline, dopamine and acetylcholine. 3 Oxytocin (400 mu/ml) abolished the response to potassium. 4 The contractions evoked in the vas deferens by field stimulation were also reduced by oxytocin (50 to 200 mg/ml). The inhibitory effect of the drug was related to the external calcium concentration. 5 It is suggested that oxytocin depresses the contractile responses in the vas deferens at least partly by reducing the availability of calcium from an extracellular source.

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