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. 1980 Mar;21(3):192-4.
doi: 10.1136/gut.21.3.192.

Hydrolysis of pyridoxal-5'-phosphate in plasma in conditions with raised alkaline phosphate

B B Anderson, H O'Brien, G E Griffin, D L Mollin

Hydrolysis of pyridoxal-5'-phosphate in plasma in conditions with raised alkaline phosphate

B B Anderson et al. Gut. 1980 Mar.

Abstract

Hydrolysis of pyridoxal phosphate in plasma was demonstrated in patients with liver disease and other conditions with raised alkaline phosphatase, and this usually closely paralleled the alkaline phosphatase level, whether of liver or bone origin. The endogenous plasma pyridoxal phosphate was inversely related to the alkaline phosphatase, and plasma hydrolysis of pyridoxal phosphate may at least in part be responsible. Very large doses of vitamin B6 may be necessary to compensate for this hydrolysis.

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