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. 1980 May;28(2):645-7.
doi: 10.1128/iai.28.2.645-647.1980.

Increased toxicity of endotoxin for tumor-bearing mice and mice responding to bacterial pathogens: macrophage activation as a common denominator

M J Berendt, M F Newborg, R J North

Increased toxicity of endotoxin for tumor-bearing mice and mice responding to bacterial pathogens: macrophage activation as a common denominator

M J Berendt et al. Infect Immun. 1980 May.

Abstract

Mice bearing the syngeneic SA-1 sarcoma or treated with live Mycobacterium bovis BCG or Formalin-killed Corynebacterium parvum acquired a greatly increased susceptibility to the lethal effects of endotoxin. In all three experimental models, the acquisition of increased sensitivity to endotoxin was concordant with the generation of a systemically activated macrophage system.

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