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. 1978 Oct 24;165(3):283-8.
doi: 10.1007/BF00332528.

Cold-sensitivity of a double mutant strain combining two ribosomal mutations in the ascomycete Podospora anserina

M Crouzet, J Bégueret

Cold-sensitivity of a double mutant strain combining two ribosomal mutations in the ascomycete Podospora anserina

M Crouzet et al. Mol Gen Genet. .

Abstract

A double mutant strain combining two ribosomal mutations conferring resistance to cycloheximide exhibits a cold-sensitive phenotype. At low temperature the biosynthesis of the 60S subunit is impaired. Genetic analysis of cold-resistant revertants have shown that this double mutant strain can be used efficiently to isolate new ribosomal mutations.

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