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. 1978 Oct 16;4(3):177-80.
doi: 10.1007/BF00777520.

The effect of the messenger RNA concentration on the competitive inhibition of translation by cap-analogues

F A Asselbergs, W H Peters, W J van Venrooij, H Bloemendal

The effect of the messenger RNA concentration on the competitive inhibition of translation by cap-analogues

F A Asselbergs et al. Mol Biol Rep. .

Abstract

Inhibition of translation of several mRNA species in a micrococcal nuclease treated reticulocyte lysate by cap analogues was compared with the competition between two mRNAs. Inhibition characteristics were very similar, only complete mRNA molecules inhibited at concentrations 150 times lower than m7 G5'ppp5'G. The inhibition of mRNA translation by cap analogues could be neutralized by the addition of extra mRNA in a manner predicted from the competitive nature of the inhibition by cap analogues.

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