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Comparative Study
. 1980 May;33(5):445-8.
doi: 10.1136/jcp.33.5.445.

Maintenance control of oral anticoagulant therapy by a chromogenic substrate assay for factor X

J G Erskine, I D Walker, J F Davidson
Comparative Study

Maintenance control of oral anticoagulant therapy by a chromogenic substrate assay for factor X

J G Erskine et al. J Clin Pathol. 1980 May.

Abstract

An amidolytic assay employing the chromogenic substrate S 2337 (Kabi Diagnostica) was used to assay factor X in 35 healthy controls and in 100 outpatients receiving oral anticoagulant therapy. This method correlated well with a coagulation assay of factor X in the control group (r = 0.88). When compared with two routine tests for the control of anticoagulant theray (Thrombotest and prothrombin ratio) good correlation was obtained between the methods, r = 0.84 and r = -0.74 respectively. These results suggest that a chromogenic substrate assay for factor X might be a suitable method for the maintenance control of oral anticoagulant therapy.

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