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. 1980 Jun;33(6):534-8.
doi: 10.1136/jcp.33.6.534.

Osteogenesis imperfecta (lethal) bones contain types III and V collagens

F M Pope, A C Nicholls, C Eggleton, P Narcissi, E N Hey, J M Parkin

Osteogenesis imperfecta (lethal) bones contain types III and V collagens

F M Pope et al. J Clin Pathol. 1980 Jun.

Abstract

Lethal osteogenesis imperfecta (OI-L) and normal fetal bones contain types I and V collagen with relatively more type V in OI-L bones. The latter, unlike normal fetal bone, also contain some type III collagen. Such altered collagen ratios could directly produce the bony fragility and radiotranslucency of OI-L bones. Since this is an inherited osteoporosis similar alterations in acquired osteoporoses are also possible.

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