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. 1980 Jun;33(6):539-54.
doi: 10.1136/jcp.33.6.539.

Immunoglobulin synthesis by neoplastic cells: models of a clonal transition from IgM to IgG synthesis

J Gordon, J L Smith

Immunoglobulin synthesis by neoplastic cells: models of a clonal transition from IgM to IgG synthesis

J Gordon et al. J Clin Pathol. 1980 Jun.

Abstract

Tumour populations from two B cell neoplasms were investigated for their capacity to synthesise immunoglobulin in vitro. Neoplastic cells from a patient with chronic lymphocytic leukaemia and an IgG lambda paraproteinaemia co-expressed surface IgG lambda and IgM lambda and synthesised both IgG lambda and IgM lambda in short-term culture. In the second patient with non-Hodgkin's lymphoma, the neoplastic cells expressed surface IgM lambda but synthesised both IgM lambda and IgG lambda in vitro. The findings are discussed in terms of a model for the clonal switch from IgM to IgG synthesis.

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