The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3methoxy-4-hydroxyphenylglycol
- PMID: 740048
- DOI: 10.1007/BF00498812
The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3methoxy-4-hydroxyphenylglycol
Abstract
The effect of acute (single dose), short-term (4 days), and chronic treatment (21 days) with two tricyclic antidepressants desipramine and amitriptyline on brain 3-methoxy-4-hydroxyphenylglycol (MHPG) was examined in the rat. Amitriptyline had no effect on brain total MHPG irrespective of the duration of the treatment and did not interfere with the lowering effect of clonidine on brain total MHPG. Acute and short-term desipramine treatment decreased brain total MHPG in rats, while chronic desipramine treatment increased it. The differential effect of acute and chronic treatment of desipramine on the brain total MHPG was further demonstrated by the lack of interference with the lowering effect of clonidine on brain total MHPG by one single dose of desipramine; partial interference after 4 days and complete interference after 21 days of desipramine treatment.
Similar articles
-
Interaction of antidepressants with clonidine on rat brain total 3-methoxy-4-hydroxyphenylglycol.Can J Physiol Pharmacol. 1979 Apr;57(4):435-7. doi: 10.1139/y79-067. Can J Physiol Pharmacol. 1979. PMID: 455145
-
Effect of acute and chronic treatment with tricyclic antidepressants on 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) contents in various regions of rat brain.Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(2):137-42. doi: 10.1016/s0278-5846(82)80189-9. Prog Neuropsychopharmacol Biol Psychiatry. 1982. PMID: 7202235
-
Chronic treatment with desipramine caused a sustained decrease of 3,4-dihydroxyphenylglycol-sulphate and total 3-methoxy-4-hydroxyphenylglycol in the rat brain.Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):87-92. doi: 10.1007/BF00505083. Naunyn Schmiedebergs Arch Pharmacol. 1977. PMID: 593430 No abstract available.
-
Effects of clonidine on desipramine- and desmethylclomipramine-induced 3-methoxy-4-hydroxyphenylglycol levels in rat brain.Eur J Pharmacol. 1993 Oct 5;242(3):301-3. doi: 10.1016/0014-2999(93)90254-f. Eur J Pharmacol. 1993. PMID: 8281994
-
Measurement of 3-methoxy-4-hydroxyphenylglycol (MHPG) in mouse brain by h.p.l.c. with electrochemical detection, as an index of noradrenaline utilisation and presynaptic alpha 2-adrenoceptor function.Br J Pharmacol. 1989 Mar;96(3):547-56. doi: 10.1111/j.1476-5381.1989.tb11852.x. Br J Pharmacol. 1989. PMID: 2541844 Free PMC article.
Cited by
-
The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.J Neural Transm. 1982;53(2-3):117-26. doi: 10.1007/BF01243403. J Neural Transm. 1982. PMID: 6978928
-
Influence of salbutamol and other beta-agonists on hypothermia induced by clonidine, apomorphine and reserpine in mice.J Neural Transm. 1981;52(4):259-67. doi: 10.1007/BF01256751. J Neural Transm. 1981. PMID: 7334362
-
Effects of combined administration of L-tryptophan and tricyclic antidepressants on alpha 2- and beta-adrenoceptors and monoamine levels in rat brain.Neurochem Res. 1985 Dec;10(12):1661-71. doi: 10.1007/BF00988608. Neurochem Res. 1985. PMID: 3003616
-
Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic alpha 2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride.Psychopharmacology (Berl). 1991;103(2):251-7. doi: 10.1007/BF02244212. Psychopharmacology (Berl). 1991. PMID: 1851309
-
The noradrenaline receptor coupled adenylate cyclase system in brain. Lack of modification by changes in the availability of serotonin.Naunyn Schmiedebergs Arch Pharmacol. 1981 Jun;316(3):218-24. doi: 10.1007/BF00505652. Naunyn Schmiedebergs Arch Pharmacol. 1981. PMID: 6265809