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. 1980 Mar;130(3):159-67.
doi: 10.1002/path.1711300304.

The breakdown of collagen by chondrocytes

R W Jubb, H B Fell

The breakdown of collagen by chondrocytes

R W Jubb et al. J Pathol. 1980 Mar.

Abstract

The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone composed of proliferating and hypertrophic chondrocytes; it is also very drastic in thin explants composed mainly of superficial fibro-cartilage.

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