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. 1980 Aug;23(8):857-61.
doi: 10.1021/jm00182a009.

Antihypertensive ureidopiperidines

J L Archibald, D R Beardsley, G M Bisset, P Fairbrother, J L Jackson, A Opalko, T J Ward

Antihypertensive ureidopiperidines

J L Archibald et al. J Med Chem. 1980 Aug.

Abstract

The synthesis of a series of 1-aralkyl-4-ureidopiperidines is reported. These compounds are related to the benzamidopiperidines exemplified by indoramin. Some of the ureidopiperidines are more potent antihypertensive agents than their benzamidopiperidine counterparts. Two examples, 1-(2-thenoyl)-3-[1-[2-(3-indolyl)ethyl]piperid-4-yl]urea and 1-(2-thenoyl)-3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperid-4-yl]urea (19 and 58), emerged as the most potent antihypertensive agents in this series.

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