Corticosteroids in the treatment of acute exacerbations of asthma

Abstract

In a 72-hour double-blind study 16 moderately to severely asthmatic subjects received either oral prednisone 2 mg/kg/day or placebo in addition to their regular medication as treatment for an acute exacerbation of asthma. The group receiving prednisone demonstrated significant increases in the PEFR and decreased need for beta-2 agonist nebulization or injections the first 12 hours of the study period and these improvements were maintained over the 72 hours. The placebo-treated group showed minimal reduction in nebulization and injection requirements and minimal increase in PEFR. Oral prednisone was found to be effective in controlling acute exacerbations of asthmatic symptoms.