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. 1980 Jun;17(6):1034-7.
doi: 10.1128/AAC.17.6.1034.

Mechanism of virucidal activity of retinoids: protein removal from bacteriophage phi 6 envelope

A Reinhardt, D Auperin, J Sands

Mechanism of virucidal activity of retinoids: protein removal from bacteriophage phi 6 envelope

A Reinhardt et al. Antimicrob Agents Chemother. 1980 Jun.

Abstract

The mechanism of the potent virucidal activity of retinol (vitamin A) and retinal (vitamin A aldehyde) was investigated for the interaction of these compounds with a model system enveloped virus, bacteriophage phi 6. The retinoids bind to and inactivate phi 6 without causing large-scale disruption of the virion. Inactivated virions have completely lost the ability to adsorb to host bacteria due to the loss of a viral envelope protein necessary for adsorption.

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References

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