An analysis of comparative carcinogenesis experiments based on multiple times to tumor

Abstract

Methods are given for the comparison of two treatment groups in experiments giving rise to multiple tumors. Methods based on the gaps in time between successive tumors are emphasized, but, for comparison, one method based directly on times to tumor is also presented. When applied to the results of an experimental animal carcinogenesis study, these analyses show that a diet supplemented with retinyl acetate reduces the hazard of mammary tumors, compared with controls, in every gap, and they allow one to combine evidence from the several gaps to obtain a powerful test for treatment effect.