Hypolipemic glucagon activity in isolated liver of genetic or acquired hypertriglyceridemic rats
- PMID: 7409295
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Hypolipemic glucagon activity in isolated liver of genetic or acquired hypertriglyceridemic rats
Diabete Metab.
1980 Jun.
Abstract
The glucagon effect (150 microgram/3 hrs) on isolated oleate-perfused (1.67 microEq/min) liver has been determined both in fa/fa obese hyperlipemic Zucker and diet-induced hyperlipemic Sprague Dawley rats and in the respective lean strains. Glucagon exerted a normal hypotriglyceridemic effect in hyperlipemic as well as in non-hyperlipemic rats. The ketone body output and the triglyceride liver content were not significantly modified by glucagon. Our data suggest that there is a normal liver responsiveness to the hyolipidemic action of glucagon and, consequently, that there is no glucagon resistance in genetically or diet-induced hyperlipermic rats.
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