Pattern of myelination and distribution of neuroglial cells along the developing optic system of the rat and rabbit

Abstract

In order to gather information about the factors influencing myelination and neuroglial cell formation in the central nervous system, the development of myelin and neuroglia was investigated along the length of the optic nerve and tract of rats and rabbits. The results of this study revealed complex developmental patterns for both of these processes. Furthermore, the pattern of myelination for the rat is different from that of the rabbit. Myelination of the rat optic pathway exhibits a general rostro-caudal gradient extending from the eye to the lateral geniculate nucleus, whereas a more homogeneous pattern is present in the rabbit. Myelination along the nerves of both species shows many sharp peaks and troughs, especially in the region of the optic canal. Formation of myelin begins at several different sites along the nerve, with the first fibers appearing on both sides of the optic canal. Another small site of myelination develops just in front of the optic chiasm. Myelination of the entire length of an individual axon is not homogeneous but instead it begins at several discrete sites. The number of glial cells along the nerve and tract also fluctuates sharply but their pattern does not precisely parallel that of myelination. A better correlation is obtained by comparing the distribution of axons being myelinated with that of oligodendroglial cells. The complex patterns and the species differences observed in this study indicate that myelination and neuroglial cell development must be regulated by both neuronal and local factors. The data presented here together with other available information suggest that the vascularization of the nerve and the direct effects of hormones upon glial cells are possible factors that contribute to the local variability.