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. 1980 Aug;75(2):189-91.
doi: 10.1111/1523-1747.ep12522644.

Immunoelectron microscopy of type III collagen in normal and scleroderma skin

R Fleischmajer, S Gay, J S Perlish, J P Cesarini
Free article

Immunoelectron microscopy of type III collagen in normal and scleroderma skin

R Fleischmajer et al. J Invest Dermatol. 1980 Aug.
Free article

Abstract

Normal and scleroderma skin was studied by indirect immuno-electron microscopy with specific antibodies against Type III collagen. Fine collagen fibrils, 200-400 A in diameter were labeled with antitype III collagen antibodies. These antibodies attached to the collagen fibril forming rings with a 650 A periodicity. Fibrils with more than 600 A in diameter were only labeled with antitype I collagen antibodies. Type III collagen was found around small blood vessels, adipocytes and smooth muscle cells, thus, corresponding to the distribution of reticulin.

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