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. 1980 Jul;53(1):28-31.
doi: 10.3171/jns.1980.53.1.0028.

Epsilon-aminocaproic acid and recurrent subarachnoid hemorrhage: a clinical trial

W A Shucart, S K Hussain, P R Cooper

Epsilon-aminocaproic acid and recurrent subarachnoid hemorrhage: a clinical trial

W A Shucart et al. J Neurosurg. 1980 Jul.

Abstract

A clinical trial of epsilon-aminocaproic acid (EACA) in preventing recurrent hemorrhage from intracranial arterial aneurysms is reported. Previous reports were reviewed, and their results concerning antifibrinolytic agents were inconclusive in establishing their efficacy. One hundred patients with documented ruptured intracranial aneurysms were admitted to this study within 48 hours of the initial hemorrhage: 45 patients received 36 gm of EACA/day, with 11 documented rebleeds and one suspected rebleed. No benefit was seen from the use of EACA.

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