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. 1980 Jul;18(1):212-4.
doi: 10.1128/AAC.18.1.212.

Hypoxanthine-arabinoside pharmacokinetics after adenine arabinoside administration to a patient with renal failure

G R Aronoff, J J Szwed, R L Nelson, E L Marcus, S A Kleit

Hypoxanthine-arabinoside pharmacokinetics after adenine arabinoside administration to a patient with renal failure

G R Aronoff et al. Antimicrob Agents Chemother. 1980 Jul.

Abstract

Hypoxanthine arabinoside pharmacokinetics were measured during an adenine arabinoside continuous intravenous infusion and during hemodialysis in a patient with renal failure. Therapeutic guidelines for adenine arabinoside in renal failure are provided based on an elimination half-life of 4.7 h and a plasma clearance of 87.9 ml/min for the hypoxanthine metabolite.

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References

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