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Comparative Study
. 1980 Oct;69(10):1232-4.

Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates

G R Roehrig, J H Billman, J Marcec, P Fritz, F Shea
  • PMID: 7420301
Comparative Study

Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates

G R Roehrig et al. J Pharm Sci. 1980 Oct.

Abstract

Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.

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