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. 1980 Oct;23(10):1130-3.
doi: 10.1021/jm00184a013.

Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator

R J Bergeron, P S Burton, K A McGovern, E J St Onge, R R Streiff

Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator

R J Bergeron et al. J Med Chem. 1980 Oct.

Abstract

A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.

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