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. 1980 Jul 8;110(27-28):1078-80.

[5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite]

[Article in German]
H R Hartmann, W Bollag
  • PMID: 7423155

[5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite]

[Article in German]
H R Hartmann et al. Schweiz Med Wochenschr. .

Abstract

5'-deoxy-5-fluorouridine (5-DFUR) exerts a marked cytostatic activity, both intraperitoneally and orally, against experimental tumors. It has a strong antitumor effect on the Crocker sarcoma S 180, the Lewis lung carcinoma and a chemically induced squamous cell carcinoma of the skin. Its ratio of antitumor activity toxicity is more favourable than that of 5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-(2-tetra-hydrofuryl)-5-fluorouracil. Mode of action and reasons for the favourable therapeutic ratio are discussed.

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