Prophylaxis against enterococcal endocarditis: comparison of the aminoglycoside component of parenteral antimicrobial regimens

Abstract

Prophylactic antibiotics for the prevention of enterococcal endocarditis are recommended for patients with valvular heart disease undergoing surgery or instrumentation of the genitourinary and gastrointestinal tracts. To evaluate the most active aminoglycoside antibiotic to include in these regimens, we administered streptomycin, gentamicin, or amikacin, each in combination with ampicillin, to six healthy adult volunteers in a crossover manner. When the sera from the volunteers were tested for bactericidal activity against 16 strains of enterococci, the gentamicin-ampicillin combination produced higher serum bactericidal levels for a longer duration of time against more strains than the other two regimens. At 1 h after antibiotic administration (a time when surgical procedures are likely to be performed), mean geometric bactericidal titers against the enterococci were 1: 7.0 for the gentamicin-ampicillin regimen, as compared with 1:3.6 and 1:3.2 for the streptomycin-ampicillin and amikacin-ampicillin combinations, respectively. Despite the lower serum levels for gentamicin, we feel that this aminoglycoside should be used in combination with ampicillin for prophylactic regimens against enterococcal endocarditis.