doi: 10.1038/bjc.1977.247.
Enhancement by cytotoxic agents of artificial pulmonary metastasis
- PMID: 74258
- PMCID: PMC2025565
- DOI: 10.1038/bjc.1977.247
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Enhancement by cytotoxic agents of artificial pulmonary metastasis
Br J Cancer.
1977 Dec.
Free PMC article
Abstract
The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.
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