Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Dec;36(6):653-8.
doi: 10.1038/bjc.1977.247.

Enhancement by cytotoxic agents of artificial pulmonary metastasis

G G Steel, K Adams
Free PMC article

Enhancement by cytotoxic agents of artificial pulmonary metastasis

G G Steel et al. Br J Cancer. 1977 Dec.
Free PMC article

Abstract

The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.

PubMed Disclaimer

References

    1. Cancer. 1975 Jan;35(1):5-14 - PubMed
    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Apr;27(4):377-87 - PubMed
    1. Cancer Res. 1975 Jun;35(6):1530-5 - PubMed
    1. Am J Pathol. 1975 Dec;81(3):513-30 - PubMed
    1. Cancer Res. 1973 Aug;33(8):1931-6 - PubMed