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. 1980 Sep;103(3):295-9.
doi: 10.1111/j.1365-2133.1980.tb07247.x.

Sister chromatid exchange and chromosome aberration rates in a group of psoriatics before and after a course of PUVA treatment

M J Faed, L Williamson, S Peterson, T Lakshmipathi, B E Johnson, W Frain-Bell

Sister chromatid exchange and chromosome aberration rates in a group of psoriatics before and after a course of PUVA treatment

M J Faed et al. Br J Dermatol. 1980 Sep.

Abstract

Blood was cultured and chromosome preparations were examined for sister chromatid exchanges and chromosome aberrations in eighteen patients receiving photochemotherapy with 8-MOP and UV-A for the treatment of psoriasis, both before starting treatment and again 6 months later. The UV-A was administered both by means of low output (irradiance: 1.1--2.25 mW/cm2) and high output (irradiance: 6.1--7.6 mW/cm2) UV-A radiation cubicles. Irrespective of the intensity of irradiation or the total dose of UV-A administered there was no evidence of chromosome damage in lymphocytes following treatment.

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