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Comparative Study
. 1980 Nov 4;602(2):260-8.
doi: 10.1016/0005-2736(80)90309-0.

Application of differential spectra in the ultraviolet-visible region to study the formation of amphotericin B-sterol complexes

I Gruda, P Nadeau, J Brajtburg, G Medoff
Comparative Study

Application of differential spectra in the ultraviolet-visible region to study the formation of amphotericin B-sterol complexes

I Gruda et al. Biochim Biophys Acta. .

Abstract

The extent of complex formation between the polyene antibiotic, amphotericin B, and cholesterol or ergosterol was investigated and a method for a quantitative measurement of the complex formation was developed. The effect of experimental conditions on the magnitude of the amphotericin B-sterol interaction and on the selectivity of this interaction showed that there was only a narrow range of solvent composition in which the differential selectivity of amphotericin B towards these two sterols could be observed.

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