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. 1980;4(2):121-5.
doi: 10.1007/BF00271095.

Electron microscopic study of the early changes proximal to a constriction in myelinated nerve

C A Logroscino, C Sanguinetti, F Catalano

Electron microscopic study of the early changes proximal to a constriction in myelinated nerve

C A Logroscino et al. Int Orthop. 1980.

Abstract

An ultrastructural study has been carried out of the changes observed proximal to a nerve constriction in rabbits. The lesion was experimentally produced with a silk ligature. Specimens were examined 24 h after ligation. Significant alterations of the ultra structure were found in sections taken at approximately 1 mm above the constriction. Examination revealed swelling of the nerve fibres due to failure of axoplasmic flow, a marked increase in the number of mitochondria, most of which showed degenerative changes and degenerative changes in the myelin sheath.

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