Marrow hypoplasia with splenomegaly in adolescence
- PMID: 7430385
- PMCID: PMC1146206
- DOI: 10.1136/jcp.33.8.730
Marrow hypoplasia with splenomegaly in adolescence
Abstract
Four adolescents presented with leucopenia, thrombocytopenia, and splenomegaly; three had associated congenital abnormalities and two had a cirrhosis. They provide further evidence of an association between hepatic disease and bone marrow dysfunction. It is considered that these patients suffer from a genetic or constitutional disorder which may result in a susceptibility of their bone marrow to hypoplasia following viral hepatitis or other infections.
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