Food and water deprivation: changes in rat feeding, drinking, activity and body weight

Abstract

Groups of male rats totally food deprived for periods up to 96 hr, water ad lib do not totally regain body weight lost through deprivation. Degree of body weight defence was estimated by fitting statistically a curve to the predeprivation baseline data and extrapolating the curve over the deprivation and postdeprivation period. From group data, body weight is not fully defended. However, marked individual differences in degree of body weight defence were noted. During food deprivation the daily drinking cycle persists for approximately 48 hr, then a reduction in nocturnal drinking appears. General activity increases but only in the light period. After food restitution, the main hyperphagia is confined to the first post-deprivation day. Additional, subtle long term effects of overeating in the light period are also found. In contrast to food deprived groups, water deprived groups accurately defend body weight. During water deprivation daily food intakes decrease immediately whereas nocturnal activity decreases after approximately 72 hr of deprivation has elapsed. After the termination of water deprivation the immediate response is gross hyperdipsia, but again subtle long term effects are apparent. Total daily food intake increases for many days but the increase is not confined to either light or dark periods. Water intake is similarly affected. These results are evaluated in relation to the notion of a body weight set-point regulating feeding behavior. Some limitations on the value of the findings in terms of species differences and lack of ecological validity are also discussed.