Immediate haemodynamic and metabolic effects of intravenous labetalol in the exercising forearm
- PMID: 7433337
Immediate haemodynamic and metabolic effects of intravenous labetalol in the exercising forearm
Abstract
Dynamic forearm exercise was performed in healthy subjects before and after intravenous labetalol, 1 mg/kg body weight. Labetalol produced a sustained fall in arterial blood pressure. Forearm blood flow decreased by 17.2% partly due to the reduced driving pressure and partly due to an increased vascular resistance. Forearm oxygen uptake decreased by 14.6%, suggesting an increased mechanical efficiency. Lactate release from the exercising forearm decreased by 17.6%. Forearm uptake of glucose and free fatty acids remained unchanged.
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