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. 1978 Dec;38(6):709-18.
doi: 10.1038/bjc.1978.277.

Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring

P Workman, C R Wiltshire, P N Plowman, N M Bleehen
Free PMC article

Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring

P Workman et al. Br J Cancer. 1978 Dec.
Free PMC article

Abstract

Concentrations of misonidazole and its O-demethylated metabolite Ro 05-9963 in the plasma and saliva of 10 patients with malignant disease have been determined. A good linear correlation was established between plasma and saliva misonidazole concentration, and salivary sampling was found to be suitable for the estimation of a number of pharmacokinetic parameters. Data are also presented for serial tumour cencentrations of misonidazole and Ro 05-9963 in 3 of the 10 patients. Monitoring of salivary misonidazole concentration appears to be a useful alternative to plasma monitoring, particularly for those patients in whom plasma sampling is unsuitable or impossible.

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