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. 1980 Nov;70(3):425-8.
doi: 10.1111/j.1476-5381.1980.tb08720.x.

4-Aminopyridine blockade of neuronal depressant responses to adenosine triphosphate

M N Perkins, T W Stone

4-Aminopyridine blockade of neuronal depressant responses to adenosine triphosphate

M N Perkins et al. Br J Pharmacol. 1980 Nov.

Abstract

1 Adenosine, adenosine monophosphate and adenosine triphosphate (ATP) depressed the firing rate of neurones in the rat cerebral cortex when applied by microinontophoresis. 2 4-Aminopyridine, also applied iontophoretically blocked the depressant effects of the purines, without affecting responses to gamma-aminobutyric acid (GABA). This blockade was effected against purine depressions of both spontaneous and glutamate-evoked activity, suggesting that the interaction occurred postsynaptically.

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References

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