Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Oct;11(1-2):117-27.
doi: 10.1016/0378-1119(80)90092-x.

Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene

N Takahashi, T Kataoka, T Honjo

Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene

N Takahashi et al. Gene. 1980 Oct.

Abstract

We have cloned a rearranged gamma 2b-chain gene from mouse myeloma MOPC141. Nucleotide-sequence determination demonstrated that the rearranged gamma 2b-chain gene was formed by a recombination between the region flanking the 5'-ends of the embryonic mu-chain gene and that of the gamma 2b-chain genes. Nucleotide sequences similar to the one located adjacent to the recombination site were found in other parts of the region flanking the 5'-end of the mu-chain-gene, as well as in the region flanking the 5'-end of the gamma 1-chain gene. The common sequence (GGTANNAAAGNAC) shares extensive homology with the sequence proximal to the insertion site of the bacterial insertion element IS2.

PubMed Disclaimer

Publication types

LinkOut - more resources