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. 1980 Aug:58:157-75.

Differentiation of glomerular filter and tubular reabsorption apparatus during foetal development of the rat kidney

J Schaeverbeke, M Cheignon
  • PMID: 7441151

Differentiation of glomerular filter and tubular reabsorption apparatus during foetal development of the rat kidney

J Schaeverbeke et al. J Embryol Exp Morphol. 1980 Aug.

Abstract

Differentiation of the glomerulus and the proximal tubule was studied in the rat foetus, especially with regard to the development of the protein filtration-reabsorption apparatus. Filtration starts several days before full differentiation of the glomerulus, when the glomerular basement membrane consists of a thin lamina alongside the podocyte membrane. Endocytosis is functional fom this time but fusion between endocytic vesicles and lysosome-like bodies occurs 2 days later. Foetal urine electrophoresis shows the presence of many proteins, including high molecular weight one, this proteinuria seeming chiefly due to the immaturity of the glomerular barrier.

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