[Metabolism of vincamine in the rat]
- PMID: 744256
[Metabolism of vincamine in the rat]
Abstract
The metabolism of vincamine hydrochloride was studied in the rat after oral administration of the drug. Vincamine is almost completely metabolized, only a small fraction of the original compound being excreted in the urine. The metabolites detected in blood, urine and tissues were purified by preparative thin layer and column chromatography in several solvent systems, and analyzed by mass spectrometry. It was found that the main urinary metabolites were vincamine conjugates (sulphates and glucuronides). Two new metabolites were detected in all the biological fluids and specimens analyzed: these compounds are more polar than vincamine and their structure was characterized by mass spectrometry, I.R. and U.V. spectroscopy and confirmed by synthesis in our laboratory.
Similar articles
-
Pharmacokinetics and metabolism of vincamine and related compounds.Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):89-103. doi: 10.1007/BF03189702. Eur J Drug Metab Pharmacokinet. 1985. PMID: 3899662 Review.
-
Metabolism of vincamine in the rat in vivo and in vitro.Arzneimittelforschung. 1980;30(11):1860-5. Arzneimittelforschung. 1980. PMID: 7192994
-
Metabolism of ethyl apovincaminate in the rat.Arzneimittelforschung. 1976;26(10a):1933-8. Arzneimittelforschung. 1976. PMID: 1037219
-
[Absorption, distribution and elimination of vincamine hydrochloride in the rat].Farmaco Prat. 1978 May;33(5):224-31. Farmaco Prat. 1978. PMID: 744225 Italian. No abstract available.
-
Antitumor antibiotic bioactivation, biotransformation and derivatization by microbial systems.Recent Results Cancer Res. 1978;63:58-68. doi: 10.1007/978-3-642-81219-4_6. Recent Results Cancer Res. 1978. PMID: 81506 Review.
Cited by
-
Pharmacokinetics and metabolism of vincamine and related compounds.Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):89-103. doi: 10.1007/BF03189702. Eur J Drug Metab Pharmacokinet. 1985. PMID: 3899662 Review.
-
Isolation and identification of twelve metabolites of isocorynoxeine in rat urine and their neuroprotective activities in HT22 cell assay.Planta Med. 2015 Jan;81(1):46-55. doi: 10.1055/s-0034-1383357. Epub 2014 Dec 17. Planta Med. 2015. PMID: 25519834 Free PMC article.
-
Vincamine Alleviates Amyloid-β 25-35 Peptides-induced Cytotoxicity in PC12 Cells.Pharmacogn Mag. 2017 Jan-Mar;13(49):123-128. doi: 10.4103/0973-1296.196309. Pharmacogn Mag. 2017. PMID: 28216895 Free PMC article.
-
Urinary metabolites of isorhynchophylline in rats and their neuroprotective activities in the HT22 cell assay.Fitoterapia. 2014 Sep;97:156-63. doi: 10.1016/j.fitote.2014.05.022. Epub 2014 Jun 6. Fitoterapia. 2014. PMID: 24910000 Free PMC article.