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. 1980 Nov;67(11):549-55.
doi: 10.1007/BF00450664.

Evolutionary constraints in the mechanism of flavin catalysis

C M Visser

Evolutionary constraints in the mechanism of flavin catalysis

C M Visser. Naturwissenschaften. 1980 Nov.

Abstract

Analysis of the possible evolution of flavin catalysis in succinate dehydrogenase suggests as the ultimate state an active site that bears one or more acid functions and uses the enediol form of the substrate rather than the carbanion as a nucleophile. In the case of flavoenzyme catalyzed oxidation of fatty acylCoA, alpha-amino acids and alpha-hydroxy acids evolution to a similar mechanism seems to be blocked.

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References

    1. FEBS Lett. 1977 Dec 1;84(1):5-21 - PubMed
    1. J Biol Chem. 1973 Oct 25;248(20):7049-54 - PubMed
    1. Am Sci. 1948 Jan;36(1):51-8 - PubMed
    1. J Biol Chem. 1977 Jul 10;252(13):4464-73 - PubMed
    1. Biochemistry. 1975 Jul 29;14(15):3482-9 - PubMed