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. 1980 Oct;314(1):13-6.
doi: 10.1007/BF00498426.

Selective inhibition by amezinium of intraneuronal monoamine oxidase

A Steppeler, K Starke

Selective inhibition by amezinium of intraneuronal monoamine oxidase

A Steppeler et al. Naunyn Schmiedebergs Arch Pharmacol. 1980 Oct.

Abstract

Intra- and extraneuronal compartments of rat hearts were selectively labelled by perfusion with 3H-noradrenaline in the presence of corticosterone 87 microM or cocaine 30 microM, respectively. The subsequent outflow of 3H-compounds was examined. As little as 1 nM amezinium diminished the outflow of intraneuronally formed 3H-DOPEG. This effect was antagonized by cocaine. Amezinium 1 microM was necessary to diminish the outflow of extraneuronally formed 3H-DOPEG. This effect was not counteracted by corticosterone. The results indicate that amezinium is both a potent and, at low concentrations, selective inhibitor of intraneuronal MAO.

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References

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    1. J Pharmacol Exp Ther. 1975 Sep;194(3):522-36 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):109-12 - PubMed
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    1. Naunyn Schmiedebergs Arch Pharmacol. 1980 Oct;314(1):1-11 - PubMed

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