doi: 10.1159/000225519.
Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222
- PMID: 7443175
- DOI: 10.1159/000225519
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Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222
Oncology.
1981.
Abstract
The preterminal intraperitoneal implanted rat leukemia L 5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU, acetamido-CNU, dihydroxypropyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed a more or less pronounced chemotherapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors of results obtained from a model which is highly sensitive to nitrosoureas is discussed.
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