Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Oct 24;8(20):4745-53.
doi: 10.1093/nar/8.20.4745.

Recognition of specific DNA sequences in eukaryotic chromosomes

H Weintraub
Free PMC article

Recognition of specific DNA sequences in eukaryotic chromosomes

H Weintraub. Nucleic Acids Res. .
Free PMC article

Abstract

The packaging of DNA into chromatin probably places certain restrictions on how specific DNA sequences can be recognized by DNA sequence specific recognition proteins (SRP). Several unique features of this type of interaction are discussed. Specifically, as a consequence of the coiling of the DNA about a histone core, it is proposed that DNA recognition sites will be compound and that each element of the compound recognition site will be about 10 - 20 b.p. in length and distributed at approximately 80 b.p. intervals--the periodicity of the DNA wrapping around the nucleosome.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1976 Jun;73(6):1897-901 - PubMed
    1. Nature. 1977 Sep 1;269(5623):29-36 - PubMed
    1. Cell. 1977 Sep;12(1):83-100 - PubMed
    1. Cell. 1977 Nov;12(3):829-36 - PubMed
    1. Nature. 1978 Feb 9;271(5645):501 - PubMed

Publication types