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Comparative Study
. 1980 Mar 11;8(5):1081-96.
doi: 10.1093/nar/8.5.1081.

Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates

M J Gait, M Singh, R C Sheppard, M D Edge, A R Greene, G R Heathcliffe, T C Atkinson, C R Newton, A F Markham
Free PMC article
Comparative Study

Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates

M J Gait et al. Nucleic Acids Res. .
Free PMC article

Abstract

A phosphotriester solid phase method on a polyamide support has been used to prepare oligodeoxyribonucleotides up to 12 units long. Compared to solid phase phosphodiester synthesis the new methodology is quicker, more flexible and gives 10-60-fold better overall yields.

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References

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